{"id":12047,"date":"2026-11-01T21:28:58","date_gmt":"2026-11-01T21:28:58","guid":{"rendered":"https:\/\/braknapost.info\/?p=12047"},"modified":"2026-11-01T21:28:58","modified_gmt":"2026-11-01T21:28:58","slug":"une-etude-universitaire-revele-des-avancees-genomiques-sur-les-virus-des-hepatites-b-et-delta-en-mauritanie","status":"publish","type":"post","link":"https:\/\/braknapost.info\/?p=12047&lang=fr","title":{"rendered":"Une \u00e9tude universitaire r\u00e9v\u00e8le des avanc\u00e9es g\u00e9nomiques sur les virus des h\u00e9patites B et Delta en Mauritanie"},"content":{"rendered":"<div class=\"container\">\n<div id=\"model-response-message-contentr_7fdb99a32d32052e\" class=\"markdown markdown-main-panel md-content enable-luminous-fast-follows enable-updated-hr-color\" dir=\"ltr\" aria-live=\"polite\">\n<p data-path-to-node=\"5\"><span class=\"\">Une \u00e9tude scientifique men\u00e9e par le doctorant Mohamed Abdaoua apporte une contribution majeure \u00e0 la caract\u00e9risation \u00e9pid\u00e9miologique et g\u00e9n\u00e9tique des virus des h\u00e9patites B (VHB) et Delta (VHD) en Mauritanie.<\/span><span class=\"\"> Publi\u00e9s dans la revue de r\u00e9f\u00e9rence <\/span><i data-path-to-node=\"5\" data-index-in-node=\"242\">Scientific Reports<\/i> du groupe Nature Portfolio, ces travaux incluent pour la premi\u00e8re fois un s\u00e9quen\u00e7age g\u00e9nomique complet du VHB \u00e0 partir d&#8217;\u00e9chantillons nationaux, offrant une cartographie pr\u00e9cise de la diversit\u00e9 virale dans le pays.<\/p>\n<p data-path-to-node=\"6\">Cette recherche est le fruit d&#8217;une coop\u00e9ration scientifique internationale supervis\u00e9e conjointement par le professeur Mohamed Vall El Mammy de l&#8217;Universit\u00e9 de Nouakchott, la professeure Fran\u00e7oise Lunel-Fabiani de l&#8217;Universit\u00e9 d&#8217;Angers et la docteure Isabelle Chemin de l&#8217;Institut de recherche sur les maladies du foie de Lyon. Elle s&#8217;inscrit dans le cadre de partenariats strat\u00e9giques entre l&#8217;Universit\u00e9 de Nouakchott, l&#8217;Institut national de recherche en sant\u00e9 publique (INRSP) et les centres de recherche sp\u00e9cialis\u00e9s fran\u00e7ais.<\/p>\n<p data-path-to-node=\"7\">L&#8217;analyse g\u00e9nomique r\u00e9v\u00e8le une pr\u00e9dominance du g\u00e9notype D du VHB (55,4 %), suivi du g\u00e9notype E (32,3 %) et du g\u00e9notype A (12,3 %), tout en identifiant une forme recombinante D\/E dans 16,9 % des cas s\u00e9quenc\u00e9s, proche d&#8217;une souche r\u00e9pertori\u00e9e au Niger. Malgr\u00e9 la d\u00e9tection de mutations rares, les marqueurs associ\u00e9s aux r\u00e9sistances aux traitements antiviraux actuels demeurent peu fr\u00e9quents. En revanche, l&#8217;\u00e9tude met en lumi\u00e8re l&#8217;impact clinique du virus Delta : 60,7 % des patients examin\u00e9s pr\u00e9sentaient des anticorps anti-VHD et 26 % une infection active, cette derni\u00e8re \u00e9tant directement corr\u00e9l\u00e9e \u00e0 une fr\u00e9quence accrue de cirrhoses et de cancers du foie.<\/p>\n<p data-path-to-node=\"8\">Face \u00e0 ces constats et rappelant que la couverture vaccinale d\u00e8s la naissance n&#8217;atteignait que 42 % en 2023 selon les donn\u00e9es de l&#8217;OMS et de l&#8217;Unicef, les chercheurs recommandent l&#8217;instauration d&#8217;un d\u00e9pistage syst\u00e9matique de l&#8217;h\u00e9patite Delta chez les porteurs du VHB. Ils pr\u00e9conisent \u00e9galement un \u00e9largissement de l&#8217;acc\u00e8s aux th\u00e9rapies antivirales et un renforcement substantiel du programme national de vaccination pour pr\u00e9venir les complications h\u00e9patiques graves au sein de la population.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Une \u00e9tude scientifique men\u00e9e par le doctorant Mohamed Abdaoua apporte une contribution majeure \u00e0 la caract\u00e9risation \u00e9pid\u00e9miologique et g\u00e9n\u00e9tique des virus des h\u00e9patites B (VHB) et Delta (VHD) en Mauritanie.\u2026<\/p>\n","protected":false},"author":10,"featured_media":12048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-12047","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sante"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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